Objective: To investigate the effects of Zhishi Xiebai Guizhi decoction on lipid metabolism and vscular endothelium in hyperlipidemia rat. Method: Using hyperlipidemia animal model replicated by hyperlipidemia forage

pravastatin sodium (3.6 mg·kg-1)and different doses of Zhishi Xiebai Guizhi decocotion (7.2

3.6

1.8 g·kg-1) were given to the model rats. Then the levels of total cholesterol(TC)

triglycerides(TG)

high-density liporotein cholesterol(HDL-C)

low-density lipoprotein cholesterol(LDL-C) and levels of nitric oxide(NO)

endothelin-1(ET-1) were assayed. Result: Compared with the normal group

the levels of TC

TG

LDL-C in the model group were increased obviously

the level of NO was decreased

the level of ET-1 was increased.Compared with the model group

the levels of TC

TG

LDL-C in the Zhishi Xiebai Guizhi decocotion high dose group and the pravastatin sodium group were decreased obviously

the level of NO was increased obviously

the level of ET-1 were decreased obviously. Conclusion: The Zhishi Xiebai Guizhi decocotion can regulate the lipid metabolism and improve vascular endothelium function in rat with hyperlipidemia.