Objective: To prepare berberine hydrochloride self-microemulsion

and investigate its quality and in vitro dissolution. Method: Prescription was optimized by orthogonal design and pseudo-ternary phase diagram with degree of emulsification

emulsion speed

oil layer and mixed-layered as indexes

prescription composition and dosage of oil phase

emulsifier and co-emulsifier from self-microemulsion system were studied

to select optimum composition and proportion of BR-SMEDDS.UV spectrophotometry was used to assess quality of BR-SMEDDS and investigate its dissolution. Result: Optimum formulations of BR-SMEDDS were composed of BR-ethyl oleate-cremophor RH40-PEG 400 0.015∶0.120∶0.160∶0.120.Particle size of droplet was 80.59 nm.In inspection of quality

The concentration of berberine hydrochloride showed a good linear relationship in 4.488-22.44 mg·L-1with absorbance(r=0.999 9)

average recovery was 100.9%

RSD 1.65%.The average content of samples was 97.4%

RSD 0.84%.Dissolution of BR-SMEDDS in artificial gastric juice was 80% in 20 min

it was higher than commercial tablets. Conclusion: BR-SMEDDS could improve dissolution of BR

and the preparation technology was simple

it would have a good applicable prospect.