Objective: To optimize preparation process of Huanglian ointment. Method: With yield of extract

the content of total alkaloid and composite score as indexes

extraction technology was optimized by orthogonal test with the concentration of ethanol

solid-liquid ratio

extraction time and extraction times as factors; Effect of five different ointment matrix prescriptions on formation and quality of Huanglian ointment was compared by stability experiment. Result: Optimum extraction process was:extracted 2 times with 6 times the amount of 70% ethanol

1.5 h per time;Ointment matrix composition as follows:octadecanol

liquid paraffin

white petrolatum

glycerin monostearate

Tween-80

Span-60

glycerin

double distilled water. Conclusion: This optimized extraction technology and ointment molding process was stable and feasible

it could be applied to large-scale production.