Objective: To study on application of statistical process control in pretreatment production process of Chinese medicine with pretreatment production process of Gardenia jasminoides from Qingkailing injection as carrier. Method: Univariate statistical process control for extraction ratio of geniposide was researched by Shewhart control chart and EWMA control chart;Based on principal component analysis model

multivariate Hotelling T2 and SPE control charts for pretreatment process of G. jasminoides were built;Technology process was diagnosed by contribution chart. Result: Shewhart and EWMA control charts could be achieved monitoring quality parameters in pretreatment technology of G. jasminoides; Multivariate statistical process control chart could be successfully applied in monitoring multiple process parameters; process analysis and fault diagnosis could be achieved by combining with contribution chart. Conclusion: Combination of univariate and multivariate statistical process control could be well monitored and understood of production process for traditional Chinese medicine.