QIAN Li-wu, DAI Wu-hao, WANG Li-li, et al. Toxicity Study on Sophocarpine and Oxysophocarpine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 256-258.
QIAN Li-wu, DAI Wu-hao, WANG Li-li, et al. Toxicity Study on Sophocarpine and Oxysophocarpine in Mice[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(13): 256-258.DOI:
Objective: To explore the acute toxicity of sophocarpine and oxysophoca rpine in Kunming mice. Method: The drugs were administered in mice via the tail vein injection. The toxic reactions were recorded and the medium lethal dose (LD50) was calculated by spss 13.0. Result: The LD50 of sophocarpine and oxysophocarpine was 63.94
250.37 mg·kg-1
its 95% confidence interval was 56.49-73.08 mg·kg-1 and 219.05-288.02 mg·kg-1
respectively. Conclusion: Acute toxicity experiment showed that the sophocarpine and oxysophocarpine have some toxic effects on mice