ZHU Peng-fei, FENG Wei-hong, DU Mao-bo, et al. Transdermal Absorption of Sanhuang Spray [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 15-17.
ZHU Peng-fei, FENG Wei-hong, DU Mao-bo, et al. Transdermal Absorption of Sanhuang Spray [J]. Chinese journal of experimental traditional medical formulae, 2012, 18(12): 15-17.DOI:
Objective: To investigate in vitro percutaneous penetration law of Sanhuang spray in mice. Method: Vertical modified Franz diffusion cell device was used with the content of baicalin and berberine hydrochloride as indexes
index ingredients in receiving liquid were determined by HPLC. Result: Transdermal rates of baicalin and berberine hydrochloride were 42.35
49.99 μg·cm-2·h-1
respectively;Average cumulative penetration rate of baicalin and berberine hydrochloride in 6 h were 19.51%
7.17%
respectively. Conclusion: In vitro transdermal absorption effect in mice of Sanhuang spray was ideal
transdermal behavior was in accordance with zero-level equation.