Objective: To observe the effects of Xinmailong capsules(XMLJ) on the blood lipid and hepatic tissue in the rats with hyperlipidemia. Method: The hyperlipidemia model was established by injected intraperitoneally(ip) vitamin D 6×105 IU·kg-1 at once and given high fat forage for four weeks. Then modeling rats were treated with different doses of XMLJ(450

300

150 mg·kg-1)

and four weeks later

the levels of blood lipid were measured

the degree of peroxide and endothelium injury were observed

including the hepatic tissue pathology. Result: The total cholesterol(TC)

triglyeeride(TG)

low density lipoprotein-cholesterol(LDL-C) and malondialdehyde(MDA)

endothelin-1(ET-1)

thromboxane B2(TXB2) at different dosages of XMLJ were significantly decreased

and the high density lipoprotein-cholesterol(HDL-C)

nitric oxide(NO)

prostacyclin (PGI2)with XMLJ were markedly increased

meanwhile

it could increase SOD activity

steatosis of hepatic tissue was significantly reduced. Conclusion: XMLJ could regulatedblood lipid level

improve antioxidation ability

enhance vascular endothelial function and relieve the liver steatosis.