Objective: To optimize extraction process of Paeonia lactiflora and Bupleurum chinense from Baijin Fuan granule. Method: With extraction volume of paeoniflorin and total saponins from B. chinense as indexes which were determined by HPLC

extraction solvent was optimized by single-factor test;With the content of paeoniflorin and total saponins from B. chinense as indexes

extraction process of Baijin Fuan granule was optimized by orthogonal test. Result: Extraction volume of paeoniflorin was the most with 70% ethanol as solvent

but when the concentration of ethanol was more than 50%

total saponins from B. chinense was basically unchanged;Optimized extraction technology was P. lactiflora and B. chinense were crushed into coarse powder

refluxing extracted 2 times with 8

6 times the amount of 70% ethanol

respectively.2 h per time. Conclusion: Optimized process was reasonable with high yield of active ingredients.