Objective: To establish a new method to evaluate and optimize extraction technology conditions of traditional Chinese medicine-similarity bid method. Method: With ethanol extract and the content of osthol as indexes

effect of the concentration of ethanol

the amount of ethanol

dipping time and percolation speed on ethanol extraction technology of compound Shechuangzi tincture by L9 (34) orthogonal test

orthogonal variance analysis and similarity bid method were used to comprehensive evaluate and optimize extraction technology of compound Shechuangzi tincture. Result: For ethanol extraction technology for compound Shechuangzi tincture

results of orthogonal test showed that optimum process in laboratory was as follows: dipped 24 h with 13 times the amount of 70% ethanol at percolation speed of 3 mL·min-1·kg-1.while results of similarity bid method showed the best industrialization process was:dipped 72 h with 11 times the amount of 70% ethanol at percolation speed of 1 mL·min-1·kg-1. Conclusion: Similarity bid method was a new and effective way in selecting and optimizing optimum industrialized extraction technology for traditional Chinese medicine with higher extraction yield and lower cost

optimized technology was stable and feasible.