Objective: To optimize extraction process of Coptis chinensis. Method: With the concentration of ethanol

the amount of solvent and extraction time as independent variables

overall desirability as dependent variable (including yield of extract

the content of berberine

coptisine and total alkaloids)

each level of independent variables were fitted by multiple linear regression and binomial formula

response surface method was used to optimize extraction process

and prediction was carried out through comparing observed and predicted value. Result: Optimal extraction process was:extracted 3 times with 10 times the amount of 50% ethanol

50 min each time.the regression coefficients of binomial fitting complex model was 0.936 2

deviation between observed and predicted value was-2.27%. Conclusion: Optimized extraction technology of C. chinensis was convenient with high predictive.