Objective: To investigate the effect and mechanism of Shenling Baizhu San on the murine model of inflammatory bowel disease(IBD) induced by dextran sodium sulfate. Method: IBD was induced by taking the drinking water added 5% dextran sodium sulphate (DSS) for 7 days. The BALB/c mice of different groups were ig administrated with normal sodium

5-aminosalicylic acid (5-ASA)

Shenling Baizhu San (12

6

3 g·kg-1)

respectively. Body weight

feces description

hemafecia

disease activity scoring(DAI)

reactive oxygen species (ROS)

myeloperoxidase(MPO)

content of malondialdehyde (MDA) in bowel tissue and histological scoring

and expression of TNF-α

IL-1β

IL-6 protein were observed. Result: Levels of ROS

MPO and MDA in DSS induced group were increased significantly and expression of tumor necrosis factor-α(TNF-α)

interleukin-1β(IL-1β)

interleukin-6(IL-6) protein were also increased. Three doses of Shenling Baizhu San could decrease ROS

MDA and MPO content

down-regulate TNF-α

IL-1β

IL-6 protein expression. Conclusion: Shenling Baizhu San can protect the damage in DSS-induced IBD in mice

which may be related to regulating inflammatory factor and scavenging oxygen free radicals.