Objective: To obtain the effect and safety of Jinshuibao capsule in treatment of patients with chronic renal failure(CRF). Method: We searched PubMed(1966—2006)

CNKI(1994—2011) databases and so on

and retrieved by computer and manual search to collect randomized controlled trial(RCT) on Jinshuibao capsule in treatment of chronic renal failure from 1979 to 2011.Two researchers independently executed a data extraction according to the inclusion criteria of Trials and quality assessment

Meta analysis was carried out. Result: A total of 8 trials involving 710 patients were included in the meta-analysis

which indicated that Jinshuibao capsule combined with conventional treatment in curing of chronic renal failure was more effective in ameliorating renal function and improving the quality of life than only using Jinshuibao capsule.These indexes included as follows:blood urea nitrogen (BUN)[MD-2.23

95%CI(-2.60

-1.85)

P<0.000 01];serum creatinine(SCr)[MD-40.71

95%CI(-45.68

-35.75)

P<0.000 01];24 hpro[MD-0.17

95%CI(-0.31

-0.03)

P=0.02]; creatinine clearance rate(CCr)[MD-25.71

95%CI(-26.36

-25.06)

P<0.000 01]。 Conclusion: Based on conventional treatment

Jinshuibao capsule can effectively relieve the progress of renal function in patient with chronic renal failure and has low side-effect

but further research work should be needed.