Objective: To optimize formulation of flavonoids from Ziziphus jujuba dripping pill. Method: Central composite design-response surface methodology was applied to optimize formulation of this drooping pill with ratio of drug-matrix

the amount of P188 and Tween-80 as independent variables

while dependent variables were T50

roundness and dissolution time

optimum mathematical model was obtained by SPSS software

which was used to fit multivariate linear model and polynomial model for experimental data.Effect diagram and contour map were draw by Origin software

optimum extraction condition was determined according to effect diagram. Result: Correlation coefficient of quadratic polynomial model was better than multivariate linear model

multiple correlation coefficient was 0.941 9

and it was determined as final fitting model;Bias between measured and predicted values of fitting model was negligible

indicating that had good predictive. Conclusion: Model established by central composite design-response surface methodology was better to predict and could be used to optimize formulation of flavonoids from Z. jujuba dripping pill.