Objective: To investigate dissolvability of total saponins from Pulsatilla chinensisand its index component in different dissolvents

and to study relationship among solubility of total saponins

solubility of index component and dispersion situation in various solvents. Method: Solubility of total saponins

solubility of index component and particle size of suspension was determined by precipitation method

index component determination method and particle size determination method. Result: Sequence of dissolvability of total saponins from P. chinensisand its index component in various solvents was:methanol>artificial colon juice>artificial small intestinal juice>distilled water>artificial gastric juice;particle size of suspension in sequence of artificial gastric juice>distilled water>artificial small intestinal juice>artificial colon juice>methanol. Conclusion: Dissolvability of total saponins from P. chinensisand its index component was maximum in methanol and minimum in artificial gastric juice

and relationship between change trend of particle size of suspension and solubility was basically negative correlation.