Objective: To investigate the effect of the water extract from Picris japoncia Thunb on blood glucose in normal mice and diabetic model mice. Method: Diabetic model in mice was induced by caudal vein injection of 50 mg·kg-1 alloxan. Mice were randomly divided into 6 groups: control group

model group

Xiaokewan pill group(0.75 g·kg-1·d-1)

low dose

moderate dose and high dose groupsof P. japoncia(1.5

3

6 g·kg-1·d-1).The drugs were administrated to mice for 14 days. Determination of fasting blood glucose by blood sampling

in the corresponding time

and acute toxicity experiment were carried out. Result: The blood glucose value of low dose

moderate dose and high dose group of P. japoncia achieved respectively was (7.52±1.47)

(7.33±2.99)

(7.79±1.84) mmol·L-1 after administrated for 14 days

there were significant difference in blood glucose value compared with model group.The acute toxicity experiment revealed that the maximum dose of intragastric administration was 120 g·kg-1. Conclusion: The total extracts of P. japoncia had obvious hypoglycemic activity and little toxicity in hyperglycemia model mice.