Objective: To study the effect of Qingrun formula on inflammation and oxidative stress of rat with diabetes mellitus. Method: The rats with diabetes mellitus were induced by intraperitoneal injection of streptozotocin and feeding with high sugar and high fat for 4 weeks. Rats with diabetes were randomly divided into five groups

three Qingrun formula groups

metformin group and model group. Other ten normal rats were made as control group. After 4 weeks

fasting blood-glucose and fasting insulin

level of serum tumor necrosis factor-α(INF-α) and interleukin-6(IL-6) of rats

the values of malondialdehyde(MDA) and superoxide dismutase(SOD) were tested when the experiment finished. Result: Compared with the model group

the levels of TNF-α were decreased in the three Qingrun formula dosage groups(P<0.05);the contents of IL-6 and MDA were decreased in the low and middle dosage groups(P<0.05); the activity of SOD were increased in the middle and high dosage groups(P<0.05). Conclusion: Qingrun formula has improvement effect on blood sugar level in rats with type 2 diabetes mellitus

which may be related to decreasing levels of cytokines and inhibit oxidative stress of the liver in rats with type 2 diabetic.