Objective: To optimize matrix prescription and determine rheological parameters of Huanglian ointment. Method: With appearance

stability constant

hot and cold damage and other factors as indexes

prescription of Huanglian ointment was optimized by uniform design method

and determined rheological parameters. Result: Optimized prescription was octadecanol 12.060 g

monostearate 10.018 g

tween-80 7.831 g

span-60 3.173 g

rheological parameters (viscosity

yield value

thixotropy

creep etc.) of Huanglian ointment were fine. Conclusion: Optimized matrix prescription was stable and feasible

it had good appearance

viscosity and ductility which were suitable for needs of production and clinical applications.