Objective: To investigate the effect of liguzinediol on the hemodynamics in acute heart failure rats. Method: Forth rats were intravenously injected pentobarbital through a micro-infusion pump and randomly divided into 5 groups: saline control group (NS)

positive control group (digoxin

22.5 μg·kg-1)

three doses of liguzinediol groups (liguzinediol 5

10

20 mg·kg-1). The heart contractile founctions such as left ventricular systolic pressure (LVSP)

maximal rising and falling rate of ventricular pressure (±dp/dtmax)

systolic arterial pressure (SAP)

diastolic arterial pressure (DAP)

heart rate (HR) were measured using a RM6240B/C four channel physiological recording instrument. Result: Liguzinediol induced significant increases of LVSP

+dp/dtmax

-dp/dtmax

and SAP. Conclusion: Liguzinediol induces a positive inotropic effect on the heart in acute heart failure rats.