To evaluate the safety and effects of Xinbao pill in treatment of sick sinus syndrome. Through searching the Cochrane Database of Controlled Trials

MEDLINE

EMbase

China Biological Medicine Database

Science Citation Index database

the United States

China

the total library network publishing academic journals

digital Academic Journal

Chinese Journal of database technology

the internet search in the research test

additional search-related conference proceedings and pharmaceutical information

two researchers independently read data included in the study the in way of cross-checking. Outcome measure indexes included: rate of pacemaker installed

the total cardiac Holter

the average heart rate

efficiency and adverse reactions.Ther qualitative analysis for data was performed by Cochrane Collaboration software Rev Man 5.0. Two hundred and twenty-two patients were included in four randomized controlled trial(RCT). Three RCT studies showed that effect of Xinbao pill was more obvious than the control group

1 RCT showed no significant difference. 1 RCT showed the average heart rate

heart holter in Xinbao pill group was significantly increased. Xinbao pill may increase heart rate in sick sinus syndrome and improve symptoms. However

more rigorous design and large samples can be needed for further confirmation.