Objective: To study the Influence of Sijunzi decoction on natural killer cell(NK) activity and serum interferon-γ(IFN- γ ) and transforming growth factor-β(TGF-β) in rats with chronic fatigue syndrome (CFS). Method: Animal model was prepared by exhaustion swimming and 20 hours' sleep deprivation.The SD rats were divided into 5 groups

model group

blank group and treatment group at low

mid and high dosage group (3.37

6.75

13.5 g·kg-1). After two weeks of treatment

NK activity and serum IFN- γ and TGF-β content were determined. Result: The NK activity and serum IFN- γ content was decreased

and TGF-β content was increased in model group

compared with blank group (P<0.01). The NK activity and serum IFN- γ content in treatment groups were higher and the TGF-β content was lower compared with model group (P<0.05); Conclusion: Sijunzi decoction could obviously enhance the NK activity and serum TGF-β content and reduce serum IFN- γ content

which could strengthen the immunity in rats with CFS.