Objective: To optimize extraction technology of Chrysanthemum indicum. Method: With the content of total flavonoids

chlorogenic acid and linarin as indexes

water extraction and ethanol extraction technology were optimized by ultrasound-assisted and orthogonal test

and compared with conventional reflux extraction;The content of total flavonoids was determined by UV

the content of chlorogenic acid and linarin were determined by RP-HPLC. Result: In total of three indexes

optimum water extraction technology was as follows:Adding 15 folds of water and extracting for 2 times

30 min each time

extraction temperature 75℃; optimum alcohol extraction process was as follows: extracted 30 min with 15 folds the amount of 80% ethanol

extraction temperature 70℃. Conclusion: Total flavonoids

chlorogenic acid and linarin were relatively high with alcohol extraction technology for C. indicum; it could provide experimental basis for comprehensive development and utilization of C. indicum.