Objective: To compare the influence of Alisma orientalis gastrin content and Na+-K+-ATP enzyme activity

and to explore the invigorating spleen function of A. orientalis before and after processing. Method: Fifty healthy male SD rats were divided randomly into the control group

the bown product low dose group

born product high dose group

the processed products low dose group

the processed products high dose group

and control group was given physiological saline

the low dose groups were given corresponding drugs at dose of 2.0 g·kg-1

the high dose groups were given corresponding drugs at dose of 6.0 g·kg-1 twice a day for 7 days. Then

the gastrin levels and duodenal Na+-K+-ATP enzyme activity

contraction amplitude

tension and the frequency of the isolated duodenal's smooth muscle of rats were measured in the Krebs solutions. Result: The gastrin content of processed products of high dose group was(3.77±0.49)ng·L-1

that was higher than that in born product high dose group s(3.24±0.13)ng·L-1(P<0.05). The Na+-K+-ATP enzyme activity in processed products of high dose group was (13.31±1.99)pmol·g-1

that was higher than that in born product high dose group(11.77±1.37)pmol·g-1 (P<0.05). High concentration in processed and born product groups could increase amplitude and relative tension of duodenum (P<0.05). Conclusion: The influence of A. orientalis on gastrin level

duodena Na+-K+-ATP enzyme and duodenal's smooth muscle is obvious

and after processed

and the actions can be enhanced.