Objective: To study the impact of Yinqin Qinggan decoction on serum nitric oxide(NO)

glutathione peroxidase(GSH-Px) in rats with alcoholic liver disease. Method: The rats were fed alcohol and high-fat diet to resultg in alcoholic liver model in rats. The rats were randomly divided into model group

control group

the Chinese medicines (Yinqin Qinggan decocotion)

west medicine group 1(tiopronin film)

west medicine group 2 (silibinin capsules)

with 30 eachgroup respectively.At 4 weeks

8 weeks and 12 weeks

respectively 10 rats in each group were executed to collect blood

sample and to measure NO

GSH-Px levels. Result: The serum levels of NO in the various stages of model group were significantly higher than the normal group (P<0.01). GSH-Px levels in the various stages was significantly lower than normal (P<0.01). Forth treatment groups in the various stages NO levels were lower than in model group (P<0.05); GSH-Px levels were significantly higher than in model group (P<0.01). Conclusion: Liver Yinqin Qinggan decoction can decrease serum NO levels

increase GSH-Px activity and inhibit of lipid peroxidation

which may be one of the mechanisms.