舒胃汤对功能性消化不良大鼠胃排空、 血清干细胞因子、一氧化氮的影响

弭艳红; 郭璇; 王小娟; 徐寅; 刘红; 张鑫; 饶文娟; 郭蕾蕾; 李永静

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舒胃汤对功能性消化不良大鼠胃排空、血清干细胞因子、一氧化氮的影响

更新时间：2024-01-04

- 舒胃汤对功能性消化不良大鼠胃排空、血清干细胞因子、一氧化氮的影响
- Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton
- 中国实验方剂学杂志 2012年18卷第3期页码：156-159
- 作者机构：
- 作者简介：
- 基金信息：
  
  长沙市科技局项目(K1001044-41)
- DOI：
  中图分类号：
- 纸质出版日期：2012
- 稿件说明：
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弭艳红, 郭璇, 王小娟, 等. 舒胃汤对功能性消化不良大鼠胃排空、血清干细胞因子、一氧化氮的影响[J]. 中国实验方剂学杂志, 2012,18(3):156-159.

MI Yan-hong, GUO Xuan, WANG Xiao-juan, et al. Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 156-159.
弭艳红, 郭璇, 王小娟, 等. 舒胃汤对功能性消化不良大鼠胃排空、血清干细胞因子、一氧化氮的影响[J]. 中国实验方剂学杂志, 2012,18(3):156-159. DOI：

MI Yan-hong, GUO Xuan, WANG Xiao-juan, et al. Influenction of Shuwei Decoction on Gastric Emptying, Serum Stem Cell Factors and Nitric Oxide in Functional Indigestion Raton[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(3): 156-159. DOI：

摘要

目的: 观察舒胃汤对功能性消化不良(FD)大鼠胃排空、血清一氧化氮(NO)、干细胞因子(SCF)的影响

探讨其可能的作用机制。方法: 大鼠随机分为空白组、模型组、木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组

每组10只。通过夹尾刺激方法建立FD模型

除空白组外其余5组每天夹尾4次

连续7 d。造模后第3天

各给药组大鼠给予相应药液ig治疗

共14 d。检测大鼠胃排空、血清NO、SCF含量变化。结果: 模型组与空白组比较胃排空延迟

血清SCF含量明显减少而NO明显升高(均P<0.05)。用药组(木香顺气丸组、莫沙必利组、舒胃汤低、高剂量组)与模型组比较胃排空(%)改善(58.35±8.71

78.17±10.74

60.39±3.48

76.80±6.96 vs 48.20±10.17

均P<0.05)

血清中SCF含量(μmol ·L-1)明显升高(19.78±2.83

26.13±4.91

19.48±1.74

24.19±3.40 vs 14.96±2.60

均P<0.05)

NO(μmol ·L-1)降低(0.18±0.01

0.16±0.01

0.18±0.01

0.16±0.01 vs 0.22±0.01

均P<0.05)。舒高组与木香顺气丸组、舒低组比较

胃排空改善(P<0.05)

血清SCF含量明显升高(P<0.05)

NO降低(P<0.05). 结论: 舒胃汤恢复胃肠道运动功可能通过调节血清NO

SCF水平的变化

促进胃排空有关。

Abstract

Objective: To observe the influences and mechanism of Shuwei decoction on gastric emptying and the content of serum nitric oxide(NO)

stem cell factors(SCF) in functional dyspepsia(FD) rats. Method: The rats were randomly divided into control group

model group

Muxiang Shunqi pill group

mosapride group

Shuwei decoction high dose group

shuwei decoction low dose group

10 rats in each group. The model of FD was established by clasping their tails

4 times each day

lated 7 days. After 3 days

except control and model groups

the rats were given corresponding drugs for 14 days. The gastric emptying

the content of serum NO and SCF were observed. Result: Compared with control group

gastric emptying was delayed in the model group rats(P<0.05)

serum SCF level was decreased (P<0.05)

serum NO level was increased(P<0.05). Compared with model group corresponding drug groups (Muxiang Shunqi pill group

mosapride group

Shuwei decoction low dose group

Shuwei decoction high dose group) improved gastric emptying ; obviously increased on serum SCF(μmol ·L-1)

decreased on serum NO(μmol ·L-1)

and structure change of ICC in gastric antrum improved. Compared with Chinese patent medicine group and Shuwei decoction low dose group

the gastric emptying was improved (P<0.05)

serum NO was decreased (P<0.05). Conclusion: Shuwei decoction can recovery the function of gastrointestinal motility by regulating the level of serum NO

SCF

promoting the gastric emptying.

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