Objective: To investigate the influence of Biyuanshu (BYS) nuclear factor-kappa B(NF- κB) p65 expression of nasal sinuses mucosa epithelial in rabbit chronic rhinosinusitis(CRS) model

and explore its possible molecular mechanism. Method: One hundred New Zealand rabbits were randomly divided into normal group

model group

sham operation group

BYS group

western medicine group

with 20 in each group

and CRS model was established. BYS group was given BYS 4.05 g·kg-1·d-1

western medicine group given clarithromycin 25 mg·kg-1·d-1 for 14 days. Nasal sinuses mucosa tissue was collected to observe nasal sinuses mucosa pathological changes with light microscopy after HE dyeing

and detect nasal sinuses mucosal epithelium cytoplasm and nucleus NF-κB p65 protein expression with Western Blotting. Result: Model group appeared chronic inflammation and inflammatory cell infiltration

epithelial cells and glandular organs and goblet cells were hyperplasia obviously. Nasal sinuses mucosal epithelium cytoplasm and nucleus NF-κB p65 protein expression was higher than normal group(P<0.01). After the treatment with BYS

the nasal sinuses mucosa epithele was improved

inflammatory cells and glandular organs and goblet cells were not hyperplasia obviously. Nasal sinuses mucosal epithelium cytoplasm NF-κB p65 protein expression was higher than normal group and sham operation group and western medicine group obviously(P<0.01)

nasal sinuses mucosal epithelium nucleus NF-κB p65 protein expression was lower than model group obviously(P<0.01)

but there were no differences among nomal group and sham operation group and western medicine group. Conclusion: NF-κB may take part in the development of CRS

BYS and suppress transposing of NF-κB p65 to cell nucleus.