Objective: To optimize extraction process of Baoxin dripping pill. Method: Ethanol extraction technology of Crataegus pinnatifida and Salvia miltiorrhiza was optimized by orthogonal test with salvianolic acid B as detection index.With the content of ferulic acid and stilbene glucoside as index

orthogonal test was used to optimize percolation process of Panax notoginseng and other herbs from Baoxin dripping pill. Result: Optimum extraction process conditions were determined as follows:C. pinnatifida and S. miltiorrhiza was extracted 3 times with 6 times the amount of 70% ethanol

1 h each time.P. notoginseng and other herbs were extracted by percolation technology

these herbs were soaked 18 h with 10 times the amount of 60% ethanol

dripping rate 10 mL·min-1. Conclusion: This optimized extraction technology of Baoxin dripping pill was stable and feasible

it could be extended to industrial production.