Objective: To observe the effects of cordyceps sinensis mycelium combined with enalapril on proteinuria in patients with early diabetic nephropathy. Method: Sixty-eight patients with early diabetic nephropathy were randomly divided into control group treated with enalapriland treatment grouptreated with enalapril and Ccordyceps Sinensis Mycelium

each group was treated for 12 weeks. The urinary albumin ejection rate(UAER)

24-hour urine protein

urine α1-microglobin(α1-MG)

β2-microglobin(β2-MG) and glycosylated hemoglobin(HbAlc) were measured before and after the treatment. Result: After treatment UAER

24-hour urine protein

α1-MG

β2-MG in both groups were significantly decreased compared with that before treatment(P<0.05)and the difference in combination group was significantly greater than that in single medication group(P<0.05).The difference of HbA1c before and after treatment had no statistical significance in both groups. Conclusion: The treatment with both cordyceps sinensis mycelium and enalapril can decrease proteinuria of Patients with early diabetic nephropathy markedly

and is better than the treatment with enalapril only.