Objective:To study the effects of Fuzheng Jiedu Granula(FJG) on the activation of nuclear factor-kappa-B(NF-κB) in rats exposed to nickel(nickel sulfate

NiSO4). Method: Rat nephrotoxicity model was established by intraperitoneal injection of NiSO4 (2.5 mg ·kg-1 ·d-1).They were randomized into 5 groups

model group

FJG high dose group (20 g ·kg-1 ·d-1)

FJG middle dose group(10 g ·kg-1 ·d-1)

FJG

low dose group(5 g ·kg-1 ·d-1)

meso-2

3-dimercaptosuccinic acid(DMSA) group(0.05 g ·kg-1 ·d-1). Twenty Wistar rats were randomly divided into NS group and FJG control group(10 g ·kg-1 ·d-1). Rats in each group were treated by intragastric administration once every day for four weeks. The levels of blood ureanitrogen(BUN)

Creatinine(Scr) and 24 hours-proteinuria(24 h-UP) were measured.The activation of NF-κB was measured with immunohistochemistry methods. Result: In FJG groups

the levels of BUN

Scr

24h-UP and the activation of NF-κB were all decreased(P<0.05

P<0.01)

compared with that of NiSO4 group. Conclusion: Inhibiting the activation of NF-κB

FJG could protect renal from injury induced by nickel.