Objective: To explore the clinical therapeutic effect and safety of combining traditional Chinese medicine (TCM) and western medicine in treatment of acute coronary syndrome (ACS). Method: ninety patients with ACS in the hospital were randomly divided into two groups

the observation group and the control group

45 cases in each group. The control group was given conventional therapy with aspirin

clopidogrel and heparin

the observation group was given conventional therapy as the control group and TCM complex prescription named Tongxinluo capsule. Result: The total efficiency in the control group was 80.00% and 95.56% in the observation which was significantly better than the control group (P<0.05); In the observation group adverse cardiovascular events (MACE) incidence was 6.67%

significantly lower than 22.22% in the control group (P<0.05). There were no serious bleeding events between the two groups. Conclusion: The therapy of combining traditional Chinese medicine and western medicine of ACS is safe

and has significant efficacy in clinical

its adverse reactions can be tolerated

it is worthy of clinical application.