Objective: To study the influence of Shenzhi Shuxue drop pills on focal cerebral ischemia model in rats. Method :The local cerebral ischemia in rat was made by middle cerebral artery occlusion

Successful model 48 rats were randomly divided into sham operation group

model control group

positive group (Xuesaitong tablets 0.04 g ·kg-1)and Shenzhi Shuxue drop pills high

medium and low dose group (0.936

0.468

0.234 g ·kg-1)

in each group 8 rats.Rats were given above medicines of 10 mL ·kg-1intragastrically once a day for 14 days. Neurological score

infarct size ratio and superoxide dismutase (SOD) activity

malondialdehyde (MDA) content in inserum were observed. Result: Shenzhi Shuxue drop pills high

medium dose group and positive group could decrease neural behavioral score

reduce infarct area ratio

increase the activity of SOD content in serum(P<0.05

P<0.01).Shenzhi Shuxue drop pills high

medium and low dose group and positive group could decrease MDA content in serum(P<0.05

P<0.01). Conclusion: Shenzhi Shuxue drop pills has protective effect on focal cerebral ischemia in rats

and its mechanism may be related toscavenging of free radical.