麝香乌龙丸对佐剂性关节炎大鼠滑膜组织病理形态及TNF-,IL-6表达的影响

陈守中; 袁强; 张爱国; 王鹏飞; 易永泽; 王志文

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麝香乌龙丸对佐剂性关节炎大鼠滑膜组织病理形态及TNF-,IL-6表达的影响

更新时间：2024-01-04

- 麝香乌龙丸对佐剂性关节炎大鼠滑膜组织病理形态及TNF-,IL-6表达的影响
- Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis
- 中国实验方剂学杂志 2012年18卷第6期页码：234-236
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- 纸质出版日期：2012
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陈守中, 袁强, 张爱国, 等. 麝香乌龙丸对佐剂性关节炎大鼠滑膜组织病理形态及TNF-,IL-6表达的影响[J]. 中国实验方剂学杂志, 2012,18(6):234-236.

CHEN Shou-zhong, YUAN Qiang, ZHANG Ai-guo, et al. Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 234-236.
陈守中, 袁强, 张爱国, 等. 麝香乌龙丸对佐剂性关节炎大鼠滑膜组织病理形态及TNF-,IL-6表达的影响[J]. 中国实验方剂学杂志, 2012,18(6):234-236. DOI：

CHEN Shou-zhong, YUAN Qiang, ZHANG Ai-guo, et al. Effect of Shexiang Wulong Wan on the Pathomorphology and Expresssion of TNF- and IL-6 in Synovium in the Rats with Adjuvant Arthritis[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 234-236. DOI：

摘要

目的: 观察麝香乌龙丸对佐剂性关节炎(AA)大鼠滑膜组织病理形态及滑膜组织中肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)表达的影响。方法: 将40只雄性Wistar大鼠随机分为正常组(A)10只

造模组30只。造模组大鼠于右后足跖皮下注射完全弗氏佐剂(CFA)0.1 mL造成AA模型。将造模成功的造模组随机分为模型组(B)、麝香乌龙丸低、高剂量组(C

n=10)

ig给予1.0

2.0 g·kg-1的麝香乌龙丸

每日1次;A

B组每日ig 生理盐水2 mL/只。30 d后

取跖趾关节

HE染色观察滑膜组织病理形态

免疫组化法检测滑膜组织中TNF-α

IL-6的表达。结果: 麝香乌龙丸低、高剂量组滑膜组织破坏程度较模型组明显减轻;TNF-α

IL-6在麝香乌龙丸低、高剂量组中表达均较模型组显著降低(P<0.01或P<0.05)

麝香乌龙丸低、高剂量组比较无统计学意义。结论: 麝香乌龙丸能改善AA大鼠滑膜组织病理损害

下调TNF-α

IL-6的表达。

Abstract

Objective: To observe the effects of Shexiang Wulong Wan(SXWLW) on the pathomorphology and tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in synovium rats with adjuvant arthritis. Method: Adjuvant arthritis (AA)animal model was reproduced.Forty Wistar male rats were divided randomly into 4 groups.model group

normal group treated with normal saline (NS)of 2 mL every day; SXWLW low dose group treated with 1.0 g·kg-1 every day; SXWLW high dose group treated with 2.0 g·kg-1 every day. At the end of the experiment

toe metatarsal joints were collected for pathological examination.The level of TNF-α and IL-6 was checked by immunohistochemical methed. Result: SXWLW low dose and high dose groups

compared with the model group

synovial tissue of damage was significantly reduced; the expression of TNF-α and IL-6 in the SXWLW low dose group and high dose group

compared with model group

decreased (P<0.01 or P<0.05). Conclusion: SXWLW can reduce the expression of TNF-α and IL-6 in the synovial tissue

therefore it could decrease synovial tissue damage.

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