Objective: To study the antiobesity function of water extract from compound aromatic plants on diet-induced obese rats. Method: The model of diet-induced obese rats was prepared by feeding high-fat diet for five weeks

then three different doses(4 000

2 000

500 mg ·kg-1) of the extract were administered respectively by gavage for another five weeks. The body weight

body fat

obesity index and Lee’s index were measured. The serum activities of leptin(LEP)

superoxide dismutase(SOD)

malondialdehyde (MDA) and total antioxidant capacity(T-AOC) were assayed by reliable reagent kits. Adipose tissue paraffin sections were examined under a light microscope. The pharmacodynamic mechanism of the extract was substantially analyzed. Result: All doses(4 000

2 000

500 mg ·kg-1)of the extract could significantly decrease body weight and body fat of obese rats(P<0.05)

and the high dose performed best with obesity index remarkably decreased(P<0.05). All doses of the extract could significantly decrease the concentration of serum LEP(P<0.05)

with a dose-dependent manner. The size of lipocytes of the high dose became smaller while the quantity of which in unit microscopic field gets larger markedly(P<0.01). All doses could significantly increase the serum activities of SOD and T-AOC

and decrease MDA levels(P<0.01)

with a dose-dependent manner. Conclusion: The water extract from the compound aromatic plants in this study functions well on weight control of diet-induced obese rats

and demonstrates distinctively anti-oxidation activity

which shows promising value of further application.