Objective: To observe the effect of Taohong Siwu granule(THSWG)on with acute myocardial ischemia injury induced by pituitrin(Pit) in rats. Method: The 70 rats were divided into normal control group

model control group

amiodarone 0.094 5 g·kg-1 group

CSDP 2.7 pills·kg-1 group

THSWG 18.36

9.18

4.59 g·kg-1 group. The rat acute myocardial ischemia injury was induced by femoral vein perfusion with Pit

and the percentage changes of the T wave and the heart rate were observed after 30

60

90 min of administration. And other rat acute myocardium ischemia models were established by sublingual venous injection of Pit

the levels of the serum creatine phosphokinase(CK) and the lactate dehydrogenase (LDH) of the rats were examined after taking THSWG for 5 days. Result: Compared with the model control group

the percentage changes of the T wave and the heart rate were significantly reduced(P<0.01)

the levels of the serum CK and LDH of the rat models were also significantly decreased(P<0.01) after taking THSWG. Conclusion: THSWG could protect the rats against acute myocardial ischemia induced by Pit.