Objective: To observe the effect of Xianhu mistura on experimental liver steatosis in rats. Method: Wistar rats were divided into normal group

model group

herbal therapy high dose group

herbal therapy low dose group

methionine group. In addition to normal group

other four groups were fed high fat diet for 10 weeks to established hyperlipemia model. Then the model group was given normal saline gavage

herbal therapy high dose group was given Xianhu mistura (31.5 g ·kg-1) gavage

low dose group was given Feiluotong mistura (15.75 g ·kg-1) gavage. Methionine group given methionine tablets gavage. Four weeks later blood biochemistry and pathological changes were examined to observe the effct of Xianhu mistura on common conditions

blood lipid level

enzyme

the ratio of liver to body weight and histological change of the fatty liver rats. Result: Xianhu mistura could decrease blood lipid level and the degree of hepatic and hepatocell necrosis. There was signifcant differences compared with DL-methionine group (P<0.05 or 0.01). Conclusion: Xianhu mistura has better effect in the treatment of hyperlipidemia fatty liver in rats.