Objective: To investigate the effect of Epimedium pubescens Maxim.(EPM)on osteoporosis in ovariectomized mouse. Method: Kunming mice were used in this study.Osteoposis model was estabished by ectomizing the ovarians of the mice. The mice were divided into six groups randomly: control group

model group

diethylstilbestrol positive control group

high dose of EPM group(200 mg·kg-1)

middle dose of EPM group(100 mg·kg-1) and low dose of EPM group(50 mg·kg-1).Sixty days after administration

bone density

the osteoclast and intelukin (IL-1β) of the bone tissue were measured. Result: The model group animals had obvious osteoporosis. EMP increased bone density

and decreased the osteoclast number and IL-1β obviously. Conlusion: EPM can increase the bone density. EPM has an apparent role of anti-osteoporosis in ovariectomized mice. And it’s mechanism may be related to the reducing of the level of IL-1β.