Objective: To study the protective effect of arctinin capsule on the nephritic rat induced by adriamycin (ADR). Method: Minimal change nephrotic rat model was induced by intravenous injection of ADR

male SD rat were randomly divided into 6 groups:Blank group

Model group

positive group

arctinin capsule high-dose group(767 mg·kg-1)

middle-dose group(383 mg·kg-1)and low-dose group(192 mg·kg-1)

treated for 6 weeks. Result: Campared with the rats in model group

arctinin capsule high-dose

middle-dose could reduced the proteinuria of the nephritic rat induced by adriamycin

increase the level of serum albumin(ALB);Arctinin capsule all the 3 doses could cut down the level of serum triglyeride(TG)and transforming growth factor-β1 (TGF-β1); Arctinin capsule high-dose(767 mg·kg-1) could increase the level of serum superoxide dismutase (SOD)and cut down the level of serum malondialdehyde (MDA);at the same time

arctinin capsule all the 3 doses could significanty ameliorated the change of pathology in renal. Conclusion: The protective action of arctinin capsule on the nephritic rat induced by adriamycin may be related to the purification on free-radical

the inhibition of lipid peroxidation and glomerular fibrosis.