Objective:To optimize technology conditions and parameters of separation and purification for total phenolic acids from Salvoa miltiorrhiza by macroporous resin. Method:Based on the content and transfer rate of total phenolic acids from S. miltiorrhiza as indexes

determined optimum separation and purification conditions of total phenolic acids from extract. Result: Optimum purification conditions were as follows: HPD100 macroporos resin was used by 20% ethanol as elution agent with ratio of resin to material drug 3∶2

ratio of diameter to height of resin column 1∶3

volume of elution agent was 8 BV

and concentration of sample was 48 g ·L-1.In these conditions

purity of total phenolic acid from S. miltiorrhiza could reach above 60%

and transfer rate was about 45%. Conclusion: Macroporous resin method was easy to operate and solvent-saving with good promotion prospects.