Objective: To compare the content of 5-hydroxymethyl furfural and gallic acid in the raw medical material and the different processed products of Cornus officinalis. Method: Kromasil®-C18(4.6 mm×250 mm

5 μm) was used. The mobile phase was acetonitrile -water (5: 95)

detection wavelength was at 240 nm for 5-hydroxymethyl furfural and methanol-0.1% phosphoric acid (8: 92)

and detection wavelength was at 271 nm for gallic acid

respectively. The flow rate was 1.0 mL·min-1 and the column temperature was at 30 ℃. Result: Compared to the C. officinalis

5-hydroxymethyl furfural was a new competent and gallic acid was significantly increased. The content of 5-hydroxymethyl furfural and gallic acid in high-pressure processed products were higher than traditional pressure products

but there was no significantly difference. Conclusion: The HPLC method developed for determination of 5-hydroxymethyl furfural and gallic acid from different processed products of C. officinalis is simple and valid. This study can provide a scientific basis for establishing rational preparing process.