Objective: To optimize extraction process of gallic acid from Phyllanthus urinaria by inner ebullition method. Method: With a small amount of ethanol as wetting agent to soak power of P. urinaria

gallic acid was resolved fully

added a certain amount of heat extraction agent to make ethanol boiling which penetrated into internal organization of P. Urinaria

enhanced extraction technology.Orthogonal test was used with the concentration of ethanol

resolution time

the amount of ethanol

extraction time and extraction temperature as factors

the content of gallic acid was determined by HPLC. Result: Optimized extraction technology of gallic acid from P. urinaria by inner ebullition method was as follows: resolved 30 min with 1.6 times the amount of 60% ethanol

extracted 15 min at 80 ℃. Conclusion: Under this optimized technology conditions

yield of gallic acid was 0.970%

and it had good application prospect.