Objective: Using Rhei Radix et Rhizome with tail clamp and senna combined with restraint to establish and evaluat irritable bowel syndrome of hepatic stagnation and spleen deficiency type. Method: The rats were randomly divided into three groups:control group(K)

Rhei Radix et Rhizome with tail clamp group(D+J)

Sennae Folium combined with restraint group

keeping modeling 7 days.All rats of control group were fed with NaCl 2 mL

Rhei Radix et Rhizome with tail clamp group was fed with 1 g·mL-1Rhei Radix et Rhizome decoction 20 g·kg-1 according to the body weight

Sennae Folium with restraint group F+S was fed with 0.36 g·mL-1 Sennae Fadium decoction 5.76 g·kg-1 according to the body weight.Watching the general behavioral activity

weight chang and the defecation

etc

after modeling evaluating the fecal points and the time of the first fecal after administration. Result: Rhei Radix et Rhizome with tail clamp and Sennae Folium combined with restraint group has the loose stools but control group has not;the weight growth rates of K

D+J

F+S were 30.24%

11.59%

11.32%;the time of the first fecal after administration were 222.91

182.61

162.36 min;the fecal points in 5 hours after modeling were 4.5

7.68

8.71;the fecal points in 24 hours after modeling were 37.14

43.49

45.54.comparing with the control group(K)

D+J

F+S group have significant difference in weight chang

the fecal points and the time of the first fecal after administration(P<0.05). Conclusion: Rhei Radix et Rhizome with tail clamp and Sennae Folumn combined with restraint group can establish irritable bowel syndrome of hepatic stagnation and spleen deficiency type successfully.