Objective:To optimize preparation technology of β-cyclodextrin(β-CD) inclusion compound for volatile oil from Baijin Fuan particle. Method:With extraction volume of volatile oil in different time as indexes

orthogonal design was used to optimize extraction processes of volatile oil from Baijin Fuan particle which including Angelica sinensis

Ligusticum chuanxiong

Curcuma longa

Paeonia suffruticosa. With encapsulation efficiency of β-CD encapsulated volatile oil as index

orthogonal design was used to optimize volatile oil inclusion process of Baijin Fuan particle. Result: A. sinensis

L. chuanxiong

C. longa

P. Suffruticosa were crushed into meal

added 5 times the amount of water

soaked 2 hours and extracted 5 h by steam distillation.Took β-CD 5 times the amount of volatile oil

added 1 time the amount of 20% ethanol

ground into paste

added volatile oil

continued to grind 2 hours

low-temperature drying. Conclusion:This optimized process was rational and with high yield of active constituents.