Objective: To design and optimize technology of artemisinin self-emulsifying preparation

and evaluate its in vitro quality evaluation. Method: Excipients was selected by determining solubility of artemidinin in different oils

surfactants and co-surfactants. Based on ternary phase diagram

artemisinin self-emulsifying prescription was optimized by central composite design method.With appearance

solubility

emulsification time

particle size after emulsified and polydispersity coefficient as indexes to do quality evaluation of artemisinin emulsifying preparation. Result: Optimum prescription of this preparation was:MCT-tween-80-ethanol 31∶37∶20

it had uniform and transparent appearance

particle size was 234.7 nm

polydispersity coefficient 0.235

self-emulsifying time was 25 s

solubility was 2.775 g·L-1. Conclusion: Technology of arteannuin self-emulsifying preparation was simple and stable

it had good physical and chemical properties.