Objective: To investigate the protective effect of Dai medicine Baogan Yihao (BGYH) on acute and chronic liver injury. Method: Three kinds of animal model were established in this study. Acute model of immunological hepatic injury was established by iv Bacillus Calmetle-Guerin(BCG)+Lipopolysaccharide(LPS) in mouse

and ConA respectively. Rat model of chronic hepatic fibrosis was developed by ih of (CCl4). BGYH with high

medium and low doses were orally administrated. Activity of alanine aminotransferase (ALT) and spartate aminotransferase (AST) in serum was determined

and pathological changes in liver were also examined. Result: BGYH at the concentration of 20.4 g·kg-1 showed significantly inhibition on the acute immunological liver injury in mice induced by BCG+LPS and ConA; BGYH at the concentration of 0.56 g·kg-1 also inhibited the chronic hepatic fibrosis induced by CCl4 in rat model. And BGYH showed protection for hepatic lesions in animal models. Conclusion: BGYH can obviously protect acute and chronic liver injuries.