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纸质出版日期:2012
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史国军, 山广志, 周宜强, 等. 中医药联合化疗治疗胃癌术后的Meta分析[J]. 中国实验方剂学杂志, 2012,18(1):261-266.
SHI Guo-jun, SHAN Guang-zhi, ZHOU Yi-qiang, et al. Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 261-266.
史国军, 山广志, 周宜强, 等. 中医药联合化疗治疗胃癌术后的Meta分析[J]. 中国实验方剂学杂志, 2012,18(1):261-266. DOI:
SHI Guo-jun, SHAN Guang-zhi, ZHOU Yi-qiang, et al. Meta-Analysis of Traditional Chinese Medicine Plus Chemotherapy in Treatment of Postoperative Gastric Cancer[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(1): 261-266. DOI:
检索中国期刊全文数据库、维普中文期刊数据库、万方学术期刊全文数据库2001.01至2010.12国内10年间的相关文献
收集中医药联合化疗治疗胃癌术后的随机对照试验(RCTs)。按纳入排除标准筛选试验、评价研究质量、提取有效数据
并采用RevMan 5.0软件进行统计分析。最终纳入21个RCT
Meta分析结果显示
①KPS评分:共有10个RCT报告
分类变量5个RCT之间无异质性
KPS评分
差异有统计学意义;连续变量5个RCT之间无异质性
KPS评分
差异有统计学意义;②免疫功能:共纳入5个RCT
各研究存在异质性
采用随机效应模型
CD3
CD4
CD4/CD8
差异均有统计学意义;③生存率:共纳入3个RCT
各研究无异质性
故采用固定效应模型
1年生存率
2年生存率
3年生存率
差异均有统计学意义;④胃肠道反应:共纳入5个RCT
各研究组无异质性
采用固定效应模型
Ⅱ度以上食欲下降
Ⅱ度以上恶心呕吐
差异均有统计学意义;⑤血细胞毒性:共纳入7个RCT
各研究无异质性
采用固定效应模型
Ⅱ度以上白细胞减少
Ⅱ度以上血红蛋白下降
Ⅱ度以上血小板下降
差异均有统计学意义。 中医药联合化疗治疗胃癌术后有效
可以改善KPS评分
提高免疫功能和生存率
减轻胃肠道反应和血细胞毒性。但由于本系统评价纳入研究的方法学质量较低
尚需开展更多设计合理、执行严格的多中心大样本且随访时间足够长的随机对照试验验证其疗效及安全性。
To evaluate the efficacy and safety of traditional Chinese medicine(TCM)in treating postoperative gastric cancer. We searched CNKI
VIP
WanFang (2001 to 2010) for randomized control trials about traditional Chinese medicine plus chemotherapy in the treatment of postoperative gastric cancer.Trial screening
quality assessment of included trials
and data extract were conducted. Statistical analysis was conductedby using RevMan 5.0 software. A total of 21 randomized controlled trials were included
meta analysis showed
① KPS score has 10 RCTs. 5 RCTs of classification variables no heterogeneity
KPS score 2.35
95%CI(1.78
3.10)
P<0.01]
5 RCTs of continuous variables no heterogeneity
KPS score
the differences are significant. ② Immune function 5 RCTs have heterogeneity and use random effects model.CD3 CD4
CD4/CD8 . The differences are significant. ③ Survival 3 RCTs have no heterogeneity
and use fixed effects model. One year survival rate is
2 year survival rate
3 year survival rate . The differences are significant. ④ Gastrointestinal reaction 5 RCTs have no heterogeneity
and use fixed effects model. Bad appetite above Ⅱ degrees is
Nausea and vomiting above Ⅱ degrees are . The differences are significant. ⑤ Blood toxicity 7 RCTs have no heterogeneity
and use fixed effects model. Leucopenia reduce above Ⅱ degrees
HB reduce above Ⅱ degrees
PLT reduce above Ⅱ degrees . The differences are significant. Traditional Chinese medicine plus chemotherapy is effective in curing postoperative gastric cancer. It can improve KPS score
immune function and survival rate
and reduce gastrointestinal reaction and blood toxicity.But the quality of studies is low
more large-scale multi-center randomized trials are needed.
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