Objective: Selected optimum preparation condition of isoliquiritigenin β-cyclodextrin(β-CD) inclusion

in order to improve solubility of water-soluble drugs. Method: Preparation technology was optimized by orthogonal test with inclusion ratio and yield as indexes

energy change of different inclusion mode and inclusion ratio was compared by computer simulation experiment

inclusion was identified by IR and XRD power diffraction

and inclusion ratio was tested by fluorometry. Result: Inclusion was prepared by saturated aqueous solution method.Optimum inclusion condition was:molar ratio of isoliquiritigenin to β-CD 1∶2

inclusion time 5 h

temperature 60 ℃.Incusion efficiency could exceed 98%

possible inclusion approach was:A ring of isoliquiritigenin was external to 1arger side of β-CD

B ring of isoliquiritigenin was external to smaller side of β-CD. Conclusion: This result showed that water solubility was obviously increased of inclusion.