Objective: To investigate the protective effects and its mechanism of supplemental Sini San on hepatic fibrosis in rats. Method: The immunohepatic fibrosis model was induced by intraperitoneal injection of porcine serum.in to rats.Eighty Wister rats were divided into eight groups: normal control group

model control group

prevention group(7 g·kg-1)

high dose group (14 g·kg-1)

mediate dose group (7 g·kg-1)

and low dose group (3.5 g·kg-1)of supplemental Sini San

colchicin control group (0.2 mg·kg-1)

Sini San control group(4 g·kg-1). Except the normal control group

all the other groups were injected with pig serum without inactivation into abdominal cavity

twice per week and 0.5 mL each time

lasting 10 weeks. The prevention group was given supplemental Sini San

10 weeks at the same time when establishment of models began

the other groups were treated with correspoding drugs after 6 weeks of modelling

and lated 10 weeks.The changes of the biochemical indicator in serum and hepatic fibrosiswere were detected respectively. Result: Compared with model group

the serum content of alanine aminotransferase(ALT)

aspartate aminotransferase(AST)

r-glutamyl transpeptadase(GGT)

alkaline phosphatase(ALP) and typeⅠ

Ⅲ

Ⅳcollage

hyaluronic acid (HA)

laminin(LN) were depressed obviously

the content of hydroxyproline (HYP) in liver tissuewas significantly lower in supplemental Sini San mediatedose group. Conclusion: Supplemental Sini San has a treatment;action on hepatic fibrosis model rats.