Objective: To observe the effects and mechanism of Shuwei decotion on the gastric emptying

substance P (SP) and gastric antrum of interstitial cells of Cajal (ICC) in functional dyspepsia (FD) with stagnation of liver-Qi and deficiency of the spleen. Method: The sixty SD rats were randomly divided into 6 groups: Shuwei decoction low dose group

Shuwei decoction high dose group

Muxiang Shunqi pill group

mosapride group

control group and model group

with 10 rats in each group. Shuwei decoction groups were administrated with Shuwei decoction at doses of 7.67 g·kg-1

30.68 g·kg-1

and muxiangshunqi pill group was given Muxiang Shunqi pill of 1.65 g·kg-1

and mosapride group was given mosapride of 1.37 mg·kg-1. The rats FD model ws maded by clasping their tails except the control group.After 3 days

the control and model groups were given distilled water ig(10 mL·kg-1); the normal group and model group were given physiological saline intragastrically; the treated rats were given corresponding drugs for 14 days. To observe gastric emptying

the content of SP were determined by radiommunoassay

structure change of interstitial cells of cajal in gastric antrum was observed by transmission electron microscope. Result: The gastric emptying was delayed and the content of SP obviously decreased(P<0.05) in model group. compared with model group

Muxiang Shunqi pill group (58.35±8.71)%

mosapride group(78.17±10.74)%

Shuwei decoction low dose group(60.39±3.48)% and Shuwei decoction high dose group(76.80±6.96)% improved gastric emptying(P<0.05); compared with SP level(5.32±2.12)ng·L-1 of model group

Muxiang Shunqi pill group(12.89±2.10) ng·L-1

mosapride group(17.86±3.56) ng·L-1

Shuwei decoction low dose group(8.03±2.51) ng·L-1 and Shuwei decoction high dose group(13.79±2.58)ng·L-1 was significantly increased the plasma SP level (P<0.05). The structure change of ICC in gastric antrum improved after treatment. Conclusion: The gastrointestinal motility in FD rats was inhibited

Shuwei decoction can regulate the level of SP

improve the structure and function of ICC in gastric antrum

promote the gastric emptying and recovery the function of gastrointestinal motility.