Objective: HPLC fingerprints of Jianwei Xiaoshi tablets were established to provide an effective method of quality control for it. Method: XDB C18 column was used with acetonitrile-0.1% phosphate aqueous as the mobile phase by gradient elution; the flow rate was 1.0 mL·min-1

and the detection wavelength was at 220 nm. Fingerprint similarity evaluation software was used to determine common fingerprint peaks

calculate the similarity

and compared with 4 counterfeit Jianwei xiaoshi tablets on the market. Result: Under 13 Jianwei Xiaoshi tablets in Jiang's fingerprint

17 common peaks were identified

the similarity was greater than 0.97

and the similarity of fingerprint of counterfeit products was less than 0.90. Conclusion: HPLC fingerprint established has better precision and reproducibility

and can effectively characterize the quality of Jianwei Xiaoshi tablets and control the product quality.