Objective: To observe effects of Wendan granulein the treatment of gastrointestinal adverse caused by highly active antiretroviral therapy(HAART). Method: One-hundred patients were divided into two groups randomly

treatment group was treated by wendan granule

control group was treated by placebo to observe the incidence of the gastrointestinal adverse and record the symptom score. Result: The incidence of gastrointestinal adverse caused by HAART in treatment group was 20.4%

while the placebo group was 48%. The symptoms score of gastrointestinal adverse between two groups showed a significant difference (P<0.05)

and the score before and after treatment in two groups was different (P<0.05). Conclusion: The wendan granule can reduce the incidence of gastrointestinal adverse caused by HAART. The treatment of Chinese medicine can significantly reduce the clinical symptoms

especially the mild or moderate symptoms.