响应面法优化黄芩中黄芩苷闪式提取工艺

范成杰; 江道峰; 凌宗士

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响应面法优化黄芩中黄芩苷闪式提取工艺

更新时间：2024-01-04

- 响应面法优化黄芩中黄芩苷闪式提取工艺
- Optimization of Flash-type Extraction Technology of Baicalin from by Response Surface Methodology
- 中国实验方剂学杂志 2012年18卷第6期页码：48-51
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- 纸质出版日期：2012
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范成杰, 江道峰, 凌宗士. 响应面法优化黄芩中黄芩苷闪式提取工艺[J]. 中国实验方剂学杂志, 2012,18(6):48-51.

FAN Cheng-jie, JIANG Dao-feng, LING Zong-shi. Optimization of Flash-type Extraction Technology of Baicalin from by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 48-51.
范成杰, 江道峰, 凌宗士. 响应面法优化黄芩中黄芩苷闪式提取工艺[J]. 中国实验方剂学杂志, 2012,18(6):48-51. DOI：

FAN Cheng-jie, JIANG Dao-feng, LING Zong-shi. Optimization of Flash-type Extraction Technology of Baicalin from by Response Surface Methodology[J]. Chinese journal of experimental traditional medical formulae, 2012, 18(6): 48-51. DOI：

摘要

目的: 利用响应面分析方法优化黄芩苷闪式提取工艺条件。方法: 以HPLC测定黄芩苷含量

以黄芩苷得率为指标

单因素试验考察乙醇体积分数、提取时间及料液比;采用Box-Behnken设计、响应面分析统计学方法对工艺参数进行优化。结果: 最佳工艺条件为14倍量70%乙醇提取102 s

在此条件下得到黄芩苷的实测值达13.588%

理论值可达13.592%

两者较吻合。结论: 闪式提取法是一种高效、快速提取黄芩中黄芩苷的方法。

Abstract

Objective: To optimize flash-type extraction technology of baicalin from Scutellaria baicalensis by response surface methodology (RSM). Method: With yield of baicalin as index

the content of baicalin was determined by HPLC. Concentration of ethanol

extracting time and liquid-material ratio were selected by single-factor test;Technology parameters were optimized by Box-Benhnken design and response surface analysis statistical method. Result: Optimal extraction technology conditions were as follows:concentration of ethanol 73%

extraction time 102 s

liquid-solid ratio 14: 1 (mL: g)

under these optimum conditions

measured value of baicalin was 13.588%

it was in line with theoretical value of 13.592%. Conclusion: Flash-type extraction was proved to be a kind of efficient and rapid method for extraction of baicalin from S. baicalensis.

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